Apogossypolone (ApoG2) - CAS 886578-07-0

Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins with K i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis [1] and autophagy [2]. Apogossypolone also has antifungal activity [3].

ROS Kinase, Apoptosis, Bcl-2 Family, Others, Antifungal, Autophagy

Tyrosine Kinase/Adaptors, Microbiology/Virology, Apoptosis, Others, Autophagy

886578-07-0

C28H26O8

490.5

C(C)(C)C1=C2C(C(=O)C(=C(C)C2=O)C=3C(=O)C=4C(C(=O)C3C)=C(C(C)C)C(O)=C(O)C4)=CC(O)=C1O

-20°C

Ice Packs

Small Compound