APOL1-IN-2 - CAS 2956781-84-1

APOL1-IN-2 (Compound 467) acts as an inhibitor of apolipoprotein L1 (APOL1) . It effectively reduces HEK293 cell death induced by APOL1 G2/G1, with EC50 values of 4.74 nM and 14.3 nM, respectively. Additionally, APOL1-IN-2 decreases the mortality of trypanosomes triggered by APOL1 G2/G1/G0, with EC50 values of 2.24, 6.03, and 3.72 nM, respectively.

Apolipoprotein

Metabolism

2956696

C28H30ClF3N4O5

595.01

O=C1C2(C=3C(N1)=CC=C(Cl)C3)CCN(CCOC=4C=C5C(=C(C(F)(F)F)C4)N(C(=O)N5CO)[C@H]6C[C@@](C)(O)C6)CC2

-20°C

Ice Packs

Small Compound