Apricitabine - CAS 160707-69-7

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.

HIV Protease, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Proteases/Proteasome

160631

>99.99%

C8H11N3O3S

229.26

O=C1N([C@@H]2S[C@H](CO)OC2)C=CC(N)=N1

-20°C

Ice Packs

Small Compound