Molfinity

APS-2-79 - CAS 2002381-25-9

SKU:MF-0063048-01

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Product Details

Bioactivity
APS-2-79, a KSR-dependent MEK antagonist, disrupts ATP (biotin) binding within the KSR2-MEK1 complex, achieving an inhibitory concentration (IC50) of 120 nM. This action stabilizes the KSR inactive state and antagonizes oncogenic Ras-MAPK signaling.
Target
Others, MEK
Related Pathways
MAPK, Others
CAS Number
2002347
Molecular Formula
C23H21N3O3
Molecular Weight
387.43
SMILES
COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3C)c2cc1OC
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound