AR antagonist 12 - CAS 2902679-42-7

AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist, demonstrating IC50 values of 119.3 μM for wt-AR and 98.2 μM for AR-F877L. It induces a dose- and time-dependent reduction in the protein levels of AR, AR-v7, and PSA. AR antagonist 12 exhibits anticancer activity, making it useful in the study of Enzalutamide-resistant prostate cancer.

Androgen Receptor

Endocrinology/Hormones

2902630

C24H23F3N6O2

484.47

C([C@](C(NC=1C=C(C(F)(F)F)C(C#N)=NC1)=O)(C)O)N2CC3N(C(C2)CC3)C4=CC=C(C#N)C=C4

-20°C

Ice Packs

Small Compound