AR antagonist 15 - CAS 1790308-86-9

AR antagonist 15 is an orally active androgen receptor (AR) antagonist with an IC50 of 97 nM for ART787A. It impairs AR nuclear translocation, hinders AR homodimerization, and inhibits AR-regulated gene transcription by competitively binding to the ligand-binding pocket. AR antagonist 15 significantly reduces prostate-specific antigen (PSA) levels and induces apoptosis by decreasing the expression of apoptosis-related proteins. This compound is useful for prostate cancer research.

Apoptosis, Androgen Receptor

Endocrinology/Hormones, Apoptosis

1790213

C18H22N2O3S

346.44

O=S(=O)(NC1=CC=C(OCC=2C=CC=CC2)C=C1)N3CCCCC3

-20°C

Ice Packs

Small Compound