ARD-2128 - CAS 2222111-87-5

ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) that degrades the androgen receptor (AR), effectively reducing AR protein levels, suppressing AR-regulated gene expression in tumor tissues, and inhibiting tumor growth without evident toxicity. This compound holds promise for prostate cancer research.

PROTACs, Androgen Receptor

PROTAC, Endocrinology/Hormones

2222019

0.9972

C45H50ClN7O6

820.37

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=C(C2)N4CCC(CN5CCN(CC5)C6=CC=C(C(N[C@@H]7C(C)(C)[C@@H](OC8=CC(Cl)=C(C#N)C=C8)C7(C)C)=O)C=C6)CC4

-20°C

Ice Packs

PROTAC