Arecaidine propargyl ester (hydrobromide) - CAS 116511-28-5

Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs) .1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively) . Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67) . It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecaidine propargyl ester decreases mean arterial blood pressure in normotensive cats (ED25= 1.9 nmol/kg) .3It is toxic to house flies (Musca) when administered at a dose of 75 μg/fly.4

Others, Apoptosis

Others, Apoptosis

116478

C10H14BrNO2

260.13

Br.CN1CCC=C(C1)C(=O)OCC#C

-20°C

Ice Packs

Small Compound