Molfinity
ARF (26–44) - CAS 935732-44-8
ARF (26–44) - CAS 935732-44-8
SKU:MF-0063153-01
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Product Details
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Bioactivity
ARF (26–44), cell-permeable is an anti-tumor peptide derived from a specific amino acid sequence of the p14ARF tumor suppressor protein. It serves as an inhibitor of FoxM1, a forkhead box M1 transcription factor, and has demonstrated significant anti-tumor activity in the treatment of mouse hepatocellular carcinoma (HCC) . This activity includes increasing apoptosis and reducing tumor cell proliferation and angiogenesis. ARF (26–44), cell-permeable is useful for research in cancer therapy.
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Target
Apoptosis
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Related Pathways
Apoptosis
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CAS Number
935732-44-8
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Molecular Formula
C149H267N69O33S
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Molecular Weight
3585.22
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SMILES
C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCCN)=O)=O)[C@@H](C)C)=O)CCCNC(=N)N)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)C(C)C)=O)=O)C)=O)CC(C)C)=O)C)=O)CS)=O)CO)=O)C)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CCC2
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Storage Temperature
-20°C
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Shipping Conditions
Ice Packs
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Category
Peptide