Arf1-GEFs-IN-1 - CAS 3091068-95-7

Arf1-GEFs-IN-1 is a potent and orally active inhibitor of ADP-ribosylation factor 1-guanine nucleotide exchange factors (Arf1-GEFs), exhibiting an IC50 value of 40 μM in CT26 cells. Primarily, Arf1-GEFs-IN-1 induces tumor regression by triggering anti-tumor immune responses rather than direct cytotoxicity. It effectively enhances CCL5 expression and demonstrates excellent in vivo efficacy. Arf1-GEFs-IN-1 is applicable in colon cancer research.

GTPase

GPCR/G Protein

3090966

C19H18N6S

362.45

N(/N=C/C=1C=C2C(=CC1)NC=C2)C3=C4C5=C(SC4=NC=N3)CN(C)CC5

-20°C

Ice Packs

Small Compound