ARN 14494 - CAS 1037837-27-6

ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM) . ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

NO Synthase, COX, Apoptosis, Interleukin, Others

Apoptosis, Immunology/Inflammation, Neuroscience, Others

1037804

C24H32N4O3

424.54

O=C1N(C=2C(C1)=CC(C(NC)=O)=CC2)C3CCN(CC(=O)N4CC5C(C4)CCC5)CC3

-20°C

Ice Packs

Small Compound