ARN1468 - CAS 1381459-14-8

ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].

PAI-1, Others

Metabolism, Others

1381437

C16H17F3N4O2

354.33

NC1=C(C=NN1C1=CC=C(OC(F)(F)F)C=C1)C(=O)C1CCNCC1

-20°C

Ice Packs

Small Compound