ARN14988 - CAS 1502027-70-4

ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme) . It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively) .

Others

Others

1501953

C16H24ClN3O5

373.83

C(OCC(C)C)(=O)N1C(=O)N(C(NCCCCCC)=O)C=C(Cl)C1=O

-20°C

Ice Packs

Small Compound