ARN23765 - CAS 2244458-40-8

ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF) .

CFTR

Membrane transporter/Ion channel

2244410

C30H22F5N3O6

615.504

O([C@@H]1C=2N(N=C(C(F)(F)F)C2CCC1)C3=CC(C(N(C)C=4C=C5C(=CC4)OC(F)(F)O5)=O)=CC=C3)C6=CC=C(C(O)=O)C=C6

-20°C

Ice Packs

Small Compound