Arnicolide D - CAS 34532-68-8

Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.

Apoptosis, Caspase, Akt, NF-κB, STAT, mTOR, ROS, PI3K

JAK/STAT signaling, NF-κB, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Apoptosis, Proteases/Proteasome, Stem Cells, Immunology/Inflammation

34456

0.9993

C19H24O5

332.39

[H][C@@]12C[C@@H](C)[C@]3([H])C=CC(=O)[C@@]3(C)[C@@H](OC(=O)C(C)=C)[C@]1([H])[C@H](C)C(=O)O2

-20°C

Ice Packs

Natural Product