ART899 - CAS 2607139-85-3

ART899, a derivative of ART558, is a potent and specific conformational inhibitor of DNA polymerase θ (Polθ) . It specifically inhibits the MMEJ activity of Polθ with an IC50 of 180 nM. Additionally, ART899 selectively enhances the radiosensitivity of tumor cells and possesses a strong independent antitumor effect on cancer cells.

DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

2607051

C19H16ClF4N3O4

464.81

C(N(C([2H])([2H])[2H])C1=CC(Cl)=C(F)C=C1)(=O)[C@H]2N(C(=O)[C@@H](O)[C@H]2O)C3=CC(C(F)(F)F)=CC(C)=N3

-20°C

Ice Packs

Isotope products