ARV-771 - CAS 1949837-12-0

ARV-771 is an effective BET degrader based on PROTAC technology. The Kd for BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2) are 34 and 4.7 respectively. , 8.3, 7.6, 9.6 and 7.6 nM.

Epigenetic Reader Domain, PROTACs

PROTAC, Chromatin/Epigenetic

1949825

0.9969

C49H60ClN9O7S2

986.64

CC=1C2=C(N3C([C@H](CC(NCCOCCCOCC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C

-20°C

Ice Packs

PROTAC