AS-99 free base - CAS 2323623-93-2

AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity, blocking cell proliferation, inducing apoptosis and differentiation, downregulating MLL fusion target genes, and reducing the leukemia burden in vivo[1].

Histone Methyltransferase, Apoptosis, Others

Others, Chromatin/Epigenetic, Apoptosis

2323528

C27H30F3N5O3S2

593.68

CN1CC(C1)C(=O)NCc1ccc2c(cn(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1)-c1cccc(c1)C(N)=S

-20°C

Ice Packs

Small Compound