AS2795440 - CAS 2171506-45-7

AS2795440 is a PIKfyve inhibitor. It selectively suppresses the production of pro-inflammatory cytokines such as IL-12p40 and IL-6 and the activation of B cells, without affecting Ca2+ signaling. In a mouse model of adjuvant-induced arthritis (AIA), AS2795440 significantly reduces joint inflammation and bone loss. This compound is useful for researching inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Interleukin, PI3K, MHC

Immunology/Inflammation, PI3K/Akt/mTOR signaling

2171454

C29H32N6O

480.6

O=C(NC=1C=C(C=NC1C)C=2C=NC(=CC2)C3=CCN(CC3)C(C)C)C4=NC5=C(C=C4)NC(=C5C)C

-20°C

Ice Packs

Small Compound