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AS2863619 free base - CAS 2241300-50-3

AS2863619 free base - CAS 2241300-50-3

MF-0004480-01

$384.33 USD
$384.33 USD
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Product Details

  • Bioactivity

    AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM) . STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.

  • Target

    CDK, STAT

  • Related Pathways

    Stem Cells, JAK/STAT signaling, Cell Cycle/Checkpoint

  • CAS Number

    2241247

  • Molecular Formula

    C16H12N8O

  • Molecular Weight

    332.32

  • SMILES

    Cc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound