Molfinity

ASB 14780 - CAS 1069046-00-9

SKU:MF-0044615

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Size 5 mg

Product Details

Bioactivity
Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (IC50 = 20 nM) . Selective for cPLA2α over secreted PLA2α (sPLA2α; exhibits no inhibition at 10 μM) . Inhibits cPLA2α-dependent inflammatory responses in vitro in guinea pig and human whole-blood assays. Improves diet-induced liver injury and CCl4-induced hepatic fibrosis in vivo. Orally bioavailable.
Target
Others
Related Pathways
Others
CAS Number
1069046-00-9
Molecular Formula
C35H38N2O6
Molecular Weight
582.697
SMILES
NC(CO)(CO)CO.OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(Oc2ccccc2)cc1
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound