ASIC1a antagonist-1 - CAS 1787243-08-6

ASIC1a antagonist-1 (Compound 5b) is an orthosteric non-competitive antagonist of the acid-sensing ion channel 1a (ASIC1a) with an IC50 of 27 nM at pH 6.7. It alters the pH dependency of ASIC1a activation and suppresses its maximum response. Additionally, ASIC1a antagonist-1 completely inhibits the induction of long-term potentiation (LTP) in the CA3-CA1 pathway. This compound is useful for research into brain diseases and pathologies.

Sodium Channel

Membrane transporter/Ion channel

1787243-08-6

C23H29Cl3N4O2

499.86

O=C1OC2=C(C=C1C(N)=N)C=CC(N(CCN(CC)CC)CC3=CC=C(C=C3)Cl)=C2.Cl.Cl

-20°C

Ice Packs

Small Compound