ASP3662 - CAS 1204178-50-6

ASP3662, also known as SPI-62, is a potent, selective and CNS-penetrable inhibitor of 11β-HSD1. The effects of ASP3662 suggest that selective inhibition of 11β-HSD1 may be an attractive approach for the treatment of neuropathic and dysfunctional pain, as observed in fibromyalgia. ASP3662 inhibited human, mouse and rat 11β-HSD1 but not human 11β-HSD2, in vitro. ASP3662 inhibited in vitro conversion of glucocorticoid from its inactive to active form in extracts of rat brain and spinal cord.

Others, Dehydrogenase

Others, Metabolism

1204122

C19H16ClF3N4O2

424.8

CN1C(=NN=C1C(OC2=C(F)C=C(Cl)C=C2F)(C)C)C3=C(F)C=C(C(N)=O)C=C3

-20°C

Ice Packs

Small Compound