Asterriquinone - CAS 60696-52-8

Asterriquinone (ARQ) is an analog of Asterriquinone and a Grb-2 binding inhibitor. It hinders the interaction between Grb-2 and tyrosine-phosphorylated EGFR, with an IC50 of 8.37 μM. Additionally, Asterriquinone serves as an HIV1 reverse transcriptase inhibitor, with a Ki of 2.3 μM, and it also inhibits the binding activities of Grb-7 and PLC-γ.

Reverse Transcriptase, EGFR, HIV Protease

Microbiology/Virology, JAK/STAT signaling, Proteases/Proteasome, Tyrosine Kinase/Adaptors, Angiogenesis

60696-52-8

C32H30N2O4

506.592

O=C1C(O)=C(C(=O)C(O)=C1C2=CN(C=3C=CC=CC23)C(C=C)(C)C)C4=CN(C=5C=CC=CC45)C(C=C)(C)C

-20°C

Ice Packs

Natural Product