ASTX295 - CAS 2093449-12-6

ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.

MDM-2/p53

Apoptosis

2093431

C33H34Cl2FNO6

630.531

O(C)[C@]1(N([C@@H]([C@@H](C(O)=O)C)C2=CC=C(Cl)C=C2)C(=O)C=3C1=C(F)C=C([C@@](CC)(O)C4CCOCC4)C3)C5=CC=C(Cl)C=C5

-20°C

Ice Packs

Small Compound