AT-1001 - CAS 1314801-63-2

AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with α3β4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal preparation, AT-1001 inhibits nicotine-induced [3H]dopamine release poorly and at significantly higher concentrations compared with mecamylamine and conotoxin MII.

AChR, Others

Neuroscience, Others

1314736

C15H21BrN2

309.24

N([C@H]1C[C@@]2(N(C)[C@](C1)(CCC2)[H])[H])C3=C(Br)C=CC=C3

-20°C

Ice Packs

Small Compound