AT-533 - CAS 908112-37-8

AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1/2, FAK, Akt/mTOR/p70S6K, . AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs) .

VEGFR, NF-κB, Akt, HSP, ERK, HIF/HIF Prolyl-Hydroxylase, FAK, HSV

PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Metabolism, Microbiology/Virology, Tyrosine Kinase/Adaptors, NF-κB, Angiogenesis, MAPK, Chromatin/Epigenetic

908067

0.9967

C23H30N4O3

410.51

Cc1nn(c2CC(C)(C)CC(=O)c12)-c1ccc(C(N)=O)c(N[C@H]2CC[C@H](O)CC2)c1

-20°C

Ice Packs

Small Compound