AT1R antagonist 3 - CAS 3053482-15-5

AT1R antagonist 3 (Compound 1) is an antagonist of the angiotensin II type 1 receptor (AT1R) and an inhibitor of the L-type calcium channel CaV1.2 (IC50=0.57 μM) . It exhibits vasodilatory effects in isolated rat aorta (10 μM, 88.7%) and shows antihypertensive activity in rat models.

Calcium Channel, RAAS

Metabolism, Membrane transporter/Ion channel, Endocrinology/Hormones

3053462

C22H16N6O2S

428.47

O=C(O)C=1C=CC=2N=C(SCC=3C=CC(=CC3)C=4C=CC=CC4C5=NN=NN5)NC2C1

-20°C

Ice Packs

Small Compound