ATC-324 - CAS 2925060-81-5

ATC-324 is a potent autophagy-targeting chimera (AUTOTAC) degrader of the androgen receptor (AR) with a DC50 of 2.05 μM. It induces autophagic-lysosomal degradation of AR, decreases nuclear AR and AR-V7 activity, and exhibits cytotoxic effects on AR-positive prostate cancer cells, making it useful for prostate cancer research.

Androgen Receptor

Endocrinology/Hormones

2924974

C53H55F6N5O10S

1068.09

S=C1N(C(=O)C(C)(C)N1C2=CC(F)=C(C(NCCOCCOCCOCCOCCNC[C@H](COC3=CC(OCC4=CC=C(F)C=C4)=C(OCC5=CC=C(F)C=C5)C=C3)O)=O)C=C2)C6=CC(C(F)(F)F)=C(C#N)C=C6

-20°C

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