Atiprimod (free base) - CAS 123018-47-3

Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis.

Others, PERK, ROS, JAK, ATG, Autophagy, STAT, p62, Apoptosis, NF-κB, Bcl-2 Family, Caspase, PARP

JAK/STAT signaling, Stem Cells, NF-κB, Proteases/Proteasome, Others, Apoptosis, Tyrosine Kinase/Adaptors, Immunology/Inflammation, Chromatin/Epigenetic, DNA Damage/DNA Repair, Autophagy, Angiogenesis

122968

C22H44N2

336.6

C(CCN(CC)CC)N1CC2(CCC(CCC)(CCC)CC2)CC1

-20°C

Ice Packs

Small Compound