ATM Inhibitor-11 - CAS 2878473-51-7

ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.

ATM/ATR

PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair

2878415

C27H33FN6O2

492.59

O=C1N(C=2C=NC=3C=C(F)C(=CC3C2N1C(C)C)C=4C=NC(OCCCN5CCN(C)CC5)=CC4)C

-20°C

Ice Packs

Small Compound