ATR-IN-14 - CAS 2765785-88-2

ATR-IN-14 (compound 1) is a powerful ATR kinase inhibitor that significantly inhibits ATR signaling pathways following CHKI protein phosphorylation, with a remarkable inhibition rate of 98.03% at 25 nM. ATR-IN-14 also exhibits notable anticancer efficacy in LoVo cells, displaying an IC50 value of 64 nM [1].

Others, ATM/ATR

PI3K/Akt/mTOR signaling, Others, DNA Damage/DNA Repair

2765695

C20H20FN7O

393.42

FC=1C2=C(C(=NC1)C=3C=CNN3)N=C(C=C2C=4N(C)N=CC4)N5[C@H](C)COCC5

-20°C

Ice Packs

Small Compound