ATR-IN-15 - CAS 2756665-52-6

ATR-IN-15 (compound 1) is a highly potent, orally active ATR kinase inhibitor with an IC50 of 8 nM. It also exhibits inhibitory activity against human colon tumor cells LoVo, DNA-PK, and PI3K, with IC50 values of 47, 663, and 5131 nM, respectively [1].

Others, ATM/ATR, DNA-PK, PI3K

PI3K/Akt/mTOR signaling, Others, DNA Damage/DNA Repair

2756607

C19H22N8O

378.43

CC=1N2C(=C(N1)C=3C=CNN3)N=C(C=C2N4[C@H](C)COCC4)C=5N(C)N=CC5

-20°C

Ice Packs

Small Compound