ATR-IN-23 - CAS 2923800-62-6

ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR) -deficient cancers [1].

ATM/ATR

DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling

2923732

C20H22N6O3S2

458.56

N(C)C=1N(C2=NC(=C3C(=N2)C(S(C)(=O)=O)=CS3)N4[C@H](C)COCC4)C=5C(N1)=CC=CC5

-20°C

Ice Packs

Small Compound