ATX inhibitor 15 - CAS 2484811-52-9

ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. It effectively inhibits ATX activity in vivo, suppresses the expression of pro-fibrotic genes, and exhibits protective effects in Bleomycin-induced lung fibrosis in mice [1].

PDE, Others

Metabolism, Others

2484750

C27H32ClN5O4S

558.09

N(C(NCC1=CC(Cl)=C(OC)C=C1)=O)C=2C=3C(N(CC)C2)=CC=C(C3)C4=NC(CN(CCO)CCO)=CS4

-20°C

Ice Packs

Small Compound