ATX inhibitor 25 - CAS 2951100-44-8

ATX inhibitor 25 (Compound 29) is an orally active Autotaxin inhibitor with an IC50 of 1.08 nM. It exhibits excellent in vitro metabolic stability, with a half-life (t1/2) of over 170 minutes. In a bleomycin-induced pulmonary fibrosis mouse model, ATX inhibitor 25 (administered orally) shows antifibrotic effects.

PDE

Metabolism

2951048

C23H20ClFN4O5

486.88

O=C(O)C1=CC(=CC=C1F)NC(=O)C=2C=3C=C(OC)C(Cl)=CC3N(C=4C=NN(C4)COC)C2C

-20°C

Ice Packs

Small Compound