ATX inhibitor 26 - CAS 2940248-11-1

ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM) -induced pulmonary fibrosis model.

PDE, JNK, ERK, p38 MAPK

Metabolism, MAPK

2940236

C18H19Cl2N7O3

452.3

O=C(OCC=1C=C(Cl)C=C(Cl)C1)N2CCC(C3=NN=C(O3)NCC4=CN=NN4)CC2

-20°C

Ice Packs

Small Compound