Aurora-A ligand 1 - CAS 2541626-73-5

Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.

Ligands for Target Protein for PROTAC, Aurora Kinase

Chromatin/Epigenetic, PROTAC, Cell Cycle/Checkpoint

2541548

C21H23N5O3

393.439

O=C(O)C1=CC=C(C=C1)NC=2N=CC=3C=C(C(=O)N(C)C)N(C3N2)C4CCCC4

-20°C

Ice Packs

PROTAC