Aurora Kinases-IN-4 - CAS 2877011-84-0

Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM. It inhibits cell proliferation in SJSA-1, MDA-MB-231, A549, and HeLa cell lines with IC50 values of 4.27, 1.54, 3.08, and 6.99 μM, respectively. This compound is applicable in research concerning triple-negative breast cancer (TNBC) [1].

Aurora Kinase

Cell Cycle/Checkpoint, Chromatin/Epigenetic

2876927

C26H28N8O

468.55

N(C=1C2=C(N=C(N1)C3=CC=C(NC(C=C)=O)C=C3)C=C(C=C2)N4CCN(C)CC4)C5=NNC(C)=C5

-20°C

Ice Packs

Small Compound