AUT2 - CAS 1311137-58-2

AUT2 is a Kv3.1 channel modulator with the potential to treat sensory hyperreactivity in patients with FXS by shifting the activation of high-threshold currents to more negative potentials. This shift reduces high-threshold K+ currents and increases low-threshold K+ currents in neurons, restoring wave IV of the ABR. Due to its ability to regulate neuronal excitability, AUT2 is also promising for the treatment of hearing impairments.

1311077

C20H20N4O3

364.4

O=C1N(C(=O)N[C@@H]1CC)C=2C=CC(OC3=CC(C(C)C)=C(C#N)C=C3)=NC2

-20°C

Ice Packs

Small Compound