AV123 - CAS 233605-81-7

AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor with an IC50 of 12.12 μM. It blocks TNF-α-induced necroptosis with an EC50 of 1.7 μM, but not apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart, and kidney, inflammatory diseases, neurodegenerative diseases, and infectious diseases [1].

Others, RIP kinase

Others, NF-κB, Apoptosis

233517

C11H14N4O2

234.25

N(=O)(=O)C=1C=C2C(N=C(NCCCC)N2)=CC1

-20°C

Ice Packs

Small Compound