Avadomide HCl - CAS 1398053-45-6

Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes degradation of Ikaros and Aiolos in diffuse large B-cell lymphoma (DLBCL) and T cells in vitro, in vivo, and in patients, resulting in both cell autonomous as well as immunostimulatory effects.

Others, Molecular Glues, NF-κB, Apoptosis, E1/E2/E3 Enzyme

Others, NF-κB, Ubiquitination, PROTAC, Apoptosis

1398002

C14H15ClN4O3

322.75

Cl.O=C1NC(=O)C(N2C(=O)C3=C(N=C2C)C=CC=C3N)CC1

-20°C

Ice Packs

Small Compound