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Molfinity

Avagacestat - CAS 1146699-66-2

Avagacestat - CAS 1146699-66-2

MF-0019233-01

$35.41 USD
$35.41 USD
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Product Details

  • Bioactivity

    Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.

  • Target

    Gamma-secretase

  • Related Pathways

    Neuroscience, Proteases/Proteasome, Stem Cells

  • CAS Number

    1146631

  • Purity

    0.9977

  • Molecular Formula

    C20H17ClF4N4O4S

  • Molecular Weight

    520.89

  • SMILES

    NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(cc1F)-c1ncon1)S(=O)(=O)c1ccc(Cl)cc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound