Avapritinib - CAS 1703793-34-3

Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.

PDGFR, c-Kit

Tyrosine Kinase/Adaptors, Angiogenesis

1703793-34-3

0.997

C26H27FN10

498.56

Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1

-20°C

Ice Packs

Small Compound