Aviculin - CAS 156765-33-2

Aviculin, a lignan glycoside, exhibits significant anticancer properties, particularly in inhibiting the metabolic activity of MCF-7 cells to below 50%, with an IC 50 value of 75.47 μM. It promotes apoptosis in breast cancer cells via the intrinsic apoptosis pathway, enhancing the expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP) . Furthermore, Aviculin leads to an increased Bax/Bcl-2 ratio, underlying its potential as an effective anticancer agent.

Others, Caspase, PARP, Apoptosis, Bcl-2 Family

Apoptosis, DNA Damage/DNA Repair, Chromatin/Epigenetic, Others, Proteases/Proteasome

156730

C26H34O10

506.54

C(O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)[C@@H]2[C@H](C=3C(C[C@H]2CO)=CC(OC)=C(O)C3)C4=CC(OC)=C(O)C=C4

-20°C

Ice Packs

Natural Product