Avitinib maleate dihydrate - CAS 1822357-78-7

Avitinib (Abivertinib) maleate dihydrate is a third-generation, irreversible, orally active selective EGFR inhibitor with IC50 values of 0.18 nM for EGFRL858R and EGFRT790M, and 7.68 nM for wild-type EGFR. Additionally, Avitinib maleate dihydrate functions as a BTK inhibitor, promoting apoptosis in mantle cell lymphoma cells and inhibiting BTK phosphorylation, demonstrating anticancer properties.

EGFR, Apoptosis, BTK

Apoptosis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis

1822272

C30H34FN7O8

639.631

OC(/C=C\C(O)=O)=O.FC1=C(N2CCN(CC2)C)C=CC(NC3=NC(OC4=CC(NC(C=C)=O)=CC=C4)=C5C(NC=C5)=N3)=C1.O.O

-20°C

Ice Packs

Small Compound