AVN-101 - CAS 1061354-48-0

AVN-101 is a highly potent 5-HT7 receptor antagonist with a Ki value of 153 pM. AVN-101 also exhibits considerable affinity for histamine H1 (Ki value of 0.58 nM) and adrenergic α2A, α2B and α2C (Ki values ​​of 0.41-3.6 nM) receptors. AVN-101 has shown good oral bioavailability and brain-blood barrier permeability, low toxicity and reasonable efficacy in animal models of central nervous system diseases.

Histamine Receptor, 5-HT Receptor, Adrenergic Receptor

Immunology/Inflammation, GPCR/G Protein, Neuroscience

1061306

0.9973

C21H25ClN2

340.89

Cl.CN1CCC2=C(C1)C1=CC(C)=CC=C1N2CCC1=CC=CC=C1

-20°C

Ice Packs

Small Compound