AXL-IN-13 - CAS 2376928-82-2

AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 of 1.6 nM and a Kd of 0.26 nM. It exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT), and inhibits cancer cell migration and invasion.

FLT, PDGFR, TAM Receptor, TGF-beta/Smad

Tyrosine Kinase/Adaptors, Stem Cells, Angiogenesis

2376844

0.9995

C34H41FN6O5

632.72

O(C=1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)N=CC1)C4=C(F)C=C(NC=5C(C(NC6CCCCC6)=O)=CN(C)N5)C=C4

-20°C

Ice Packs

Small Compound