AY 77 - CAS 1835734-92-3

AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM) . AY 77 can promote migration of human breast cancer cells in vitro.

Protease-activated Receptor, ERK, Calcium Channel

Metabolism, GPCR/G Protein, MAPK, Membrane transporter/Ion channel

1835639

0.997

C21H32N4O4

404.5

[C@H](CC1CCCCC1)(C(N[C@H](C(N)=O)[C@@H]2CCCCC2)=O)NC(=O)C3=CC=NO3

-20°C

Ice Packs

Peptide