AZ 1729 - CAS 2016864-46-1

FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively) . Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro.

GPCR, Others

Endocrinology/Hormones, GPCR/G Protein, Others

2016864-46-1

C18H16FN5OS

369.42

Cc1nc(NC(N)=N)sc1-c1cccc(NC(=O)c2ccc(F)cc2)c1

-20°C

Ice Packs

Small Compound